Clinical Resolution Laboratory

Clinical Resolution Laboratory, Inc. (CRL) is a United States skincare company and medical-device manufacturer based in Brea, California. Founded in 2000, it develops cosmeceutical skincare alongside microneedling devices, and describes itself as a pioneer of derma-needling technology [8]. The company sells both directly to consumers and to licensed aesthetic professionals, and remains active, with regular editorial publishing continuing into 2026 [11].

The business sits across two pillars: topical skincare formulated around peptides, growth factors, retinol and hyaluronic acid, and a line of professional treatment tools led by the InnoPen microneedling device. CRL states that its formulations are made in the USA and developed in-house by a team of chemists.

CRL traces its founding to 2000, a date stated on its professional website and corroborated by the third-party directory Beauty Launchpad, which describes the company as "a United States medical device manufacturer and product development laboratory that has been a leader and pioneer of the microneedling industry since 2000" [5][8]. The company's own materials frame this longevity as a roughly two-decade history in skin rejuvenation and professional skincare.

The names of CRL's founders and any parent company are not disclosed in the company's published materials or in the third-party sources covering it; the firm appears to be privately held with leadership it does not publicize.

CRL's product range spans serums, moisturizers, masks and topical treatments. Among the items it features prominently are the Advanced 247 Repair Serum, described by the company as an age-defying formula combining growth factors and peptides, the StemPep Moisturizer, and the Peptide HR Complex aimed at hair thinning. Formulations draw on ingredients including peptides, growth factors, retinol, hyaluronic acid, PDRN and collagen.

A distinct part of the business is numbing products for use before procedures. Its Numb Master cream, a 5% lidocaine topical anesthetic, is registered as an over-the-counter drug; it appears in the FDA's structured product labeling under the labeler name Clinical Resolution Laboratory, Inc. [10]. The product is positioned for use ahead of microneedling treatments.

On the professional side, CRL develops a branded microneedling system comprising the InnoPen device, the InnoTip needle cartridge and the MTS Roller. According to the company, the InnoPen is "the world's most advanced and safe microneedling device" [6]. Beauty Launchpad describes CRL as the sole developer of the InnoPen and MTS Roller and characterizes the tools as "uniquely patented" [8]. The UK aesthetics directory Consulting Room independently describes the InnoPen as "a precision micro-needling device with a patented InnoTip," a dual spring-loaded single-use needle cartridge with adjustable depth, and names CRL among the pioneers in derma-needling technology [9]. No patent number is given in the available sources.

The company positions itself as a clinical, science-led developer of skincare and aesthetic devices for both personal and professional use. It says its chemists research advanced ingredients to create proprietary formulations, and states a focus on safety, efficacy and innovation [1]. Its mission, as worded on the professional site, is "to deliver the most innovative products and devices in the aesthetic industry," guided by what it calls a philosophy of excellence in science and superior knowledge [5]. Products are sold across a multi-channel model: a direct-to-consumer storefront at clinicalresolution.com and a separate business-to-business site, skincarecrl.com, serving licensed professionals.

CRL markets its products under several formulation claims. The company states that its products are cruelty-free, paraben-free and dye-free, and made in the USA [2]. On its professional site it adds that products are free from synthetic dyes, fragrances and mineral oils. No third-party certifications are listed in the available sources.

CRL has not been the subject of mainstream consumer beauty editorial, and no English-language Wikipedia article exists for it, which is consistent with its standing as a professional and clinical supplier rather than a mass-market label. Third-party visibility comes mainly from trade and aesthetics channels: the Beauty Launchpad company directory, the Consulting Room treatment listing for the InnoPen, and the FDA drug listing for Numb Master. The company also exhibits at industry trade shows and supplies professional distributors in the United States and Canada.

The company is active. It maintains a weekly editorial blog, with posts continuing through April 2026, keeps a live FDA over-the-counter drug listing for Numb Master, and operates both its consumer and professional websites [11]. Its distribution reaches professionals beyond the US, with stockists in Canada, giving it a multi-region footprint.