111SKIN

111SKIN is a London-based luxury skincare brand founded in 2012 by the plastic surgeon Dr Yannis Alexandrides and his wife, Eva Alexandrides [2]. It grew out of Dr Yannis's clinical practice at 111 Harley Street, where he treated patients before and after surgery, and the brand still positions itself at the meeting point of cosmetic surgery and at-home skincare. The company remains independently owned and operates internationally, trading as 111 SKIN LTD in the United Kingdom [10].

The brand describes its purpose as bringing "surgically-precise skincare for visible results" to the market, and it has become known for a small number of high-priced hero products, treatment masks and a doctor-led research story carried by its founder.

According to the company, Dr Yannis Alexandrides created 111SKIN after concluding that the clinical-strength products available to his surgical patients were too harsh: clients found them "too irritating and abrasive" for skin recovering from procedures. His stated reasoning was direct — "if the right product doesn't exist, then why not make it yourself?" Drawing on more than two decades of practice at 111 Harley Street, he set out to develop formulas potent enough for post-procedure skin yet gentle enough for sensitive skin.

The result was a proprietary reparative complex the brand calls NAC Y2, built around N-Acetyl Cysteine. The first product, a healing serum that became the Repair Serum NAC Y2, reportedly worked so well that patients began seeking it out for everyday use, which prompted the wider launch of the brand in 2012.

Eva Alexandrides is named as co-founder. The company credits her with the brand's "sensorial" side — how products look and feel — and with leading its philanthropic work, including partnerships with Women for Women International and the sustainability body Positive Luxury.

111SKIN presents itself as a "luxury, doctor-led brand that bridges the gap between plastic surgery and skincare." The company frames its formulas as "grounded in innovation and backed by science," with an emphasis on results that are visible and on suitability for sensitive skin "without compromising on potency or efficacy." Beyond individual products, it promotes what it calls "360° skin health," combining its skincare range with affiliated spa and clinic services, including cryotherapy and heat treatments offered under the 111CRYO and 111SKIN SPA/CLINIC names. The brand sits firmly in the luxury tier and sells directly through its own multi-region online store, with separate pricing for the UK, Europe, the United States and the rest of the world.

The brand's cornerstone is the NAC Y2 complex. According to 111SKIN, it combines three actives — N-Acetyl Cysteine as the core compound, vitamin C described as an antioxidant that "preserves the integrity of NAC," and escin, said to improve oxygen delivery to the skin — delivered through an encapsulated system intended to release the ingredients gradually. The Repair Serum NAC Y2, launched in 2012, was the first product to carry the complex and evolved from Dr Yannis's original clinical healing serum.

A recurring element of the brand's story is a link to space research. The company says NAC is "a trusted clinical compound used in medicine and even studied for protecting astronauts against oxidative stress in space" [6], a claim echoed independently by Marie Claire, which reported that the founder "helped create a serum for NASA astronauts to combat space's advancing ageing effects" [7].

The brand's most visible products are its treatment masks. Its hydrogel sheet masks — the Rose Gold and Celestial Black Diamond lines — have become a backstage fixture used before events and shows, and HELLO! magazine reported that they had passed 18 million sales [9]. The Celestial Black Diamond eye masks combine ingredients such as hyaluronic acid, retinol and what the brand calls black diamond particles. More recently, 111SKIN extended its range with Concentrates, a line of high-potency ampoules that the founder describes as delivering "medical-grade results without downtime" [8].

111SKIN is closely associated with celebrity and red-carpet clientele. Press profiles have named Jennifer Aniston, Victoria Beckham, Kim and Khloe Kardashian, Priyanka Chopra and others among users of its masks and serums, and the brand's products have been used for high-profile magazine shoots. Its sheet masks have been described in beauty press as a "backstage wonder," and the company received a Harper's Bazaar Best of Beauty award in the skincare category in 2024 [12].

The brand's stated commitments centre on philanthropy and accredited standards rather than formal eco-certifications. Since 2018 it has held Positive Luxury's Butterfly Mark, a certification for sustainability and philanthropy that it says it has subsequently renewed [4]. The company donates all profits from its Rose Gold Radiance Body Oil to Women for Women International, offers customers a £1 donation option at checkout, and publishes instructions for recycling its glass packaging.

111SKIN is active. It operates as an independent UK company with international e-commerce across multiple currencies, runs an affiliated spa and clinic, and has continued to launch products and attract editorial coverage into 2024 and 2025, including the Concentrates ampoule range [8]. No parent company is recorded; the business appears to remain founder-owned.